Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes
نویسندگان
چکیده
منابع مشابه
nano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
چکیده ندارد.
Limitations of allotopic expression of mitochondrial genes in mammalian cells.
The possibility of expressing mitochondrial DNA-coded genes in the nuclear-cytoplasmic compartment provides an attractive system for genetic treatment of mitochondrial disorders associated with mitochondrial DNA mutations. In theory, by recoding mitochondrial genes to adapt them to the universal genetic code and by adding a DNA sequence coding for a mitochondrial-targeting sequence, one could a...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2020
ISSN: 2213-2317
DOI: 10.1016/j.redox.2020.101429